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She told Sirius Radio in the U. The Material Girl defended her controversial crucifixion scene in last year's Confessions tour, saying: "We all need to be Jesus. She said of the show, which featured video messages of Aids orphans in Africa: "For me, we all need to be Jesus in our time.

Of course some people thought, 'Oh she's just being controversial, she's just getting on a cross and trying to piss people off,' but that wasn't my intention at all. Madonna, who has modelled herself on Eva Peron and Marilyn Monroe in the past, added: "I'd like to think I am taking people on a journey; I am not just entertaining people, but giving them something to think about when they leave.

In comments which may annoy her British film-director husband Guy Ritchie, the star, who has been under fire for her adoption of Malawian baby David Banda, shed light on her friendships with gay men. People online quoted her as saying: "Gay men are perfect men for girls who are tough. They're not threatened by strong women, and they're usually very in touch with their feelings and pay attention to details. I've always had an affinity with gay men. Argos AO. Latest Headlines U. Madonna: 'I want to be like Gandhi' Last updated at 16 February Madonna says she is not content to be the Queen of Pop - she wants to be like Gandhi.

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Return of the flying car, just when we all need to escape Something for the Weekend, Sir? This study builds upon the pilot work undertaken in the case series study by implementing a powered randomised controlled study, with the aims of: 1 Establishing the effectiveness of core stability training; 2 Comparing core stability training with standardised physiotherapy exercise; 3 Exploring underlying mechanisms of change associated with this intervention This is a multi-centre , double blind, block randomised, controlled trial.

In addition, ultrasound imaging of the abdominal muscles will be performed before. Hollands, Kristen L. Objectives Given the importance of vision in the control of walking and evidence indicating varied practice of walking improves mobility outcomes, this study sought to examine the feasibility and preliminary efficacy of varied walking practice in response to visual cues, for the rehabilitation of walking following stroke.

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Design This 3 arm parallel, multi-centre , assessor blind, randomised control trial was conducted within outpatient neurorehabilitation services Participants Community dwelling stroke survivors with walking speed adaptability practice using visual cues are feasible and may improve mobility and balance. Future studies should continue a carefully phased approach using identified methods to improve retention. Trial Registration Clinicaltrials. A pragmatic multi-centre randomised controlled trial of fluid loading and level of dependency in high-risk surgical patients undergoing major elective surgery: trial protocol.

Full Text Available Abstract Background Patients undergoing major elective or urgent surgery are at high risk of death or significant morbidity. Measures to reduce this morbidity and mortality include pre-operative optimisation and use of higher levels of dependency care after surgery. We propose a pragmatic multi-centre randomised controlled trial of level of dependency and pre-operative fluid therapy in high-risk surgical patients undergoing major elective surgery.

The first randomisation is to pre-operative fluid therapy or standard regimen and the second randomisation is to routine intensive care versus high dependency care during the early post-operative period. We intend to recruit patients undergoing major elective and urgent abdominal and thoraco-abdominal surgery who fulfil high-risk surgical criteria. The primary outcome for the comparison of level of care is cost-effectiveness at six months and for the comparison of fluid optimisation is the number of hospital days after surgery.

Discussion We believe that the results of this study will be invaluable in determining the future care and clinical resource utilisation for this group of patients and thus will have a major impact on clinical practice. Design and performance of a multi-centre randomised controlled trial and economic evaluation of joint tele-consultations [ISRCTN Full Text Available Abstract Background Appropriate information flow is crucial to the care of patients, particularly at the interface between primary and secondary care.

Communication problems can result from inadequate organisation and training, There is a major expectation that information and communication technologies may offer solutions, but little reliable evidence. This paper reports the design and performance of a multi-centre randomised controlled trial RCT, unparalleled in telemedicine research in either scale or range of outcomes. The study investigated the effectiveness and cost implications in rural and inner-city settings of using videoconferencing to perform joint tele-consultations as an alternative to general practitioner referral to the hospital specialist in the outpatient clinic.

All the patients who gave consent to participate were randomised either to joint tele-consultation or to a routine outpatients appointment. The principal outcome measures included the frequency of decision by the specialist to offer a follow-up outpatient appointment, patient satisfaction Ware Specific Questionnaire, wellbeing SF12 and enablement PEI, numbers of tests, investigations, procedures and treatments. Results A total of general practitioners operating from 29 practices participated in the trial, referring a total of patients to 20 specialists in ENT medicine, general medicine including endocrinology, and rheumatology, gastroenterology, orthopaedics, neurology and urology.

Of these, patients consented to participate in the study and were correctly randomised. Conclusion We have designed and. A multi-centre randomised controlled trial of rehabilitation aimed at improving outdoor mobility for people after stroke: Study protocol for a randomised controlled trial.

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This study is testing the clinical effectiveness and cost effectiveness of a new outdoor mobility rehabilitation intervention by comparing it to usual care. Participants are being randomly allocated to either the intervention group or the control group. Intervention group participants receive up to 12 rehabilitation outdoor mobility sessions over up to four months. The main component of the intervention is repeated practice of outdoor mobility with a therapist.

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Control group participants are receiving the usual intervention for outdoor mobility limitations: verbal advice and provision of leaflets provided over one session. Outcome measures are being collected using postal questionnaires, travel calendars and by independent assessors. The primary outcome measure is the Social Function domain of the SF36v2 quality of life assessment six months after recruitment. The secondary outcome measures include: functional ability, mobility, the number of journeys monthly travel diaries, satisfaction with outdoor mobility, mood, health-related quality of life, resource use of health and social care.

Carer mood information is also being collected. The mean Social Function score of the SFv2 will be compared between treatment arms using a multiple membership form of mixed effects multiple regression analysis adjusting for centre as a fixed effect, age and baseline Social Function score as covariates and therapist as a multiple membership random effect.

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CoDuSe group exercise programme improves balance and reduces falls in people with multiple sclerosis: A multi-centre , randomized, controlled pilot study. Imbalance leading to falls is common in people with multiple sclerosis PwMS. A multi-centre , randomized, controlled single-blinded pilot study with random allocation to early or late start of exercise, with the latter group serving as control group for the physical function measures. In total, 14 supervised minute exercise sessions were delivered over 7 weeks. Pretest-posttest analyses were conducted for self-reported near falls and falls in the group starting late.

A total of 51 participants were initially enrolled; three were lost to follow-up. No other significant differences were found between groups. In the group starting late, numbers of falls and near falls were statistically significantly reduced after exercise compared to before p balance and reduced perceived walking limitations, compared to no exercise. The intervention reduced falls and near falls frequency. Surgical timing after chemoradiotherapy for rectal cancer, analysis of technique STARRCAT : results of a feasibility multi-centre randomized controlled trial.

The optimal time of rectal resection after long-course chemoradiotherapy CRT remains unclear. A feasibility study was undertaken for a multi-centre randomized controlled trial evaluating the impact of the interval after chemoradiotherapy on the technical complexity of surgery. For blinded technical complexity assessment, the Observational Clinical Human Reliability Analysis technique was used to quantify technical errors enacted within video recordings of operations.

Other measured outcomes included resection completeness, specimen quality, radiological down-staging, tumour cell density down-staging and surgeon-reported technical complexity.

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Fewer eligible patients were identified than had been predicted. Of 23 patients who underwent resection, mean Other measured outcomes were similar between groups. The feasibility of measurement of operative performance of rectal cancer surgery as an endpoint was confirmed in this exploratory study. Recruitment of sufficient numbers of patients represented a challenge, and a proportion of patients did not proceed to resection surgery. These results suggest that interval after CRT may not substantially impact upon surgical technical performance.

European multi-centre case- control study on risk factors for rare cancers of unknown aetiology. To search for occupational risk factors, we conducted a case- control study in nine European countries of cancers of the small intestine, male gall bladder, thymus, bone, male breast, melanoma of the eye, and mycosis fungoides. Recruitment was population based in Denmark, Latvia, France, Germany It was possible to undertake this complicated study across Europe, but we encountered three main problems.

It was difficult to ensure complete case ascertainment, for population controls , we found a clear divide Low social interactions in eating disorder patients in childhood and adulthood: a multi-centre European case control study. The objective of this article was to examine lifestyle behaviours in eating disorder ED patients and healthy controls.

A total of ED patients and healthy controls from five European countries completed the questions related to lifestyle behaviours of the Cross-Cultural Questionnaire CCQ. For children, the ED sample exhibited more solitary activities rigorously doing homework [psocializing with friends [pgroup and this continued in adulthood. There were minimal differences across ED sub-diagnoses and various cross-cultural differences emerged. Reduced social activities may be an important risk and maintaining factor for ED symptomatology.

Oxygen titration after resuscitation from out-of-hospital cardiac arrest: a multi-centre , randomised controlled pilot study the EXACT pilot trial. However, the feasibility and safety of oxygen titration in the prehospital setting is unknown.